- physiology of movement disorders
- deep brain stimulation
- interventional MRI-guided neurosurgery
Philip Starr, M.D., Ph.D.
Professor, University of California, San Francisco
My research goals are (1) to understand the pathophysiology of movement disorders, and mechanism of deep brain stimulation (DBS), using the combined basal ganglia and cortical recording in humans undergoing surgery; and (2) develop novel stimulation paradigms to improve clinical therapies.
Swann NC, de Hemptinne C, Aron AR, Ostrem JL, Knight RT, and Starr PA (2015). “Elevated synchrony in Parkinson disease detected with electroencephalography.” Ann Neurol. 78(5):742-50.
Miocinovic S, de Hemptinne C, Qasim S, Ostrem JL, and Starr PA (2015). “Patterns of Cortical Synchronization in Isolated Dystonia Compared With Parkinson Disease.” JAMA Neurol. 72(11):1244-51.
de Hemptinne C, Swann NC, Ostrem JL, Ryapolova-Webb ES, San Luciano M, Galifianakis NB, and Starr PA (2015). “Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson’s disease.” Nat Neurosci 18:779-787.
de Hemptinne C, Ryapolova-Webb ES, Air EL, Garcia PA, Miller KJ, Ojemann JG, Ostrem JL, Galifianakis NB, and Starr PA (2013). “Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease.” Proceedings of the National Academy of Sciences of the United States of America 110:4780-4785.
Shimamoto SA, Ryapolova-Webb ES, Ostrem JL, Galifianakis NB, Miller KJ, and Starr PA (2013). “Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson’s disease.” J Neurosci 33:7220-7233.
Crowell AL, Ryapolova-Webb ES, Ostrem JL, Galifianakis NB, Shimamoto S, Lim DA, and Starr PA (2012). “Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study.” Brain,135 (Pt 2):615-30.
Ostrem JL, Racine CA, Glass GA, Grace JK, Volz MM, Heath SL, and Starr PA (2011). “Subthalamic nucleus deep brain stimulation in primary cervical dystonia.” Neurology, 76(10):870-8.
Air EL, Ostrem JL, Sanger TD, and Starr PA (2011). “Deep brain stimulation in children: experience and technical pearls.” J Neurosurg Pediatr. (6):566-74.
Starr PA, Ostrem JL, Martin A, Talke P, Levesque N, and Larson P (2010). “Subthalamic nucleus deep brain stimulator placement using high field interventional MRI and a skull-mounted aiming device: technique and application accuracy.” J Neurosurg, (112): p479-90.