Contact

Office: Sandler room 514F, UCSF Misson Bay Campus
e: loren@phy.ucsf.edu
p: 415-502-6317
w: http://phy.ucsf.edu/~loren/

Reasearch Areas
  • Learning
  • Memory
  • Decision making
  • Cognitive neuroprosthetics

Loren Frank

Associate Professor, University of California, San Francisco

The ability to store experiences and then use them to guide behavior is one of the most remarkable abilities of the brain. Our goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions.   In particular, our laboratory focuses on the circuitry of the hippocampus and  anatomically related regions.   We use a combination of techniques, including large scale multielectrode recording, targeted optogenetic interventions and behavioral manipulations of awake, behaving animals to understand how the brain  learns and remembers.

Publications

Singer AC, Carr MF, Karlsson MP, Frank LM (2013). Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task. Neuron. March 20; 77(6): 1163-1173.

Carr MF, Karlsson MP, Frank LM. (2012). Transient slow gamma synchrony underlies hippocampal memory replay. Neuron. 75(4):700-713.

Jadhav SP, Kemere C, German PW, Frank LM. (2012). Awake hippocampal sharp-wave ripples support spatial memory. Science. 336(60 87):1454-1458.

Carr MF, Jadav S, Frank LM. (2011) Hippocampal replay in the awake state: a potential physiological substrate of memory consolidation and retrieval. Nature Neuroscience. Jan 26;14:147-153.

Singer AC, Frank LM (2009) Reward enhances reactivation of recent experience in the hippocampus. Neuron. Dec 24; 64(6): 910-921

Karlsson MP, Frank LM (2009) Awake replay of remote experiences in the hippocampus. Nature Neuroscience. Jul;12(7):913-8.