- Decision making
- Cognitive neuroprosthetics
Associate Professor, University of California, San Francisco
The ability to store experiences and then use them to guide behavior is one of the most remarkable abilities of the brain. Our goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions. In particular, our laboratory focuses on the circuitry of the hippocampus and anatomically related regions. We use a combination of techniques, including large scale multielectrode recording, targeted optogenetic interventions and behavioral manipulations of awake, behaving animals to understand how the brain learns and remembers.
Rothschild G, Eban E, and Frank LM. “A cortical-hippocampal-cortical loop of information processing during memory consolidation.” Nat Neurosci. (2017).
Jadhav SP, Rothschild G, Roumis DK, and Frank LM. “Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events.” Neuron (2016).
Kay K, Sosa M, Chung JE, Karlsson MP, Larkin MC, and Frank LM. “A hippocampal network for spatial coding during immobility and sleep.” Nature (2016).
Singer AC, Carr MF, Karlsson MP, and Frank LM. “Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task.” Neuron (2013).
Carr MF, Karlsson MP, and Frank LM. “Transient slow gamma synchrony underlies hippocampal memory replay.” Neuron (2012).
Jadhav SP, Kemere C, German PW, and Frank LM. “Awake hippocampal sharp-wave ripples support spatial memory.” Science (2012).
Carr MF, Jadav S, and Frank LM. “Hippocampal replay in the awake state: a potential physiological substrate of memory consolidation and retrieval.” Nature Neuroscience (2011).