- Neural mechanisms of motivation, learning, choice, and action
- Effects of neurological & psychiatric disorders
Joshua Berke, Ph.D.
Professor, University of California, San Francisco
Director, Alcohol and Addiction Research Group
Department of Neurology
Josh Berke’s laboratory at UCSF seeks to understand how we normally make adaptive, motivated decisions, and how the underlying neural mechanisms malfunction in psychiatric and neurological disorders. Their particular focus is cortical – basal ganglia circuits and their associated neuromodulators such as dopamine. To investigate these mechanisms they use electrophysiology, electrochemistry and optogenetic methods in combination with sophisticated behavioral tasks, and develop advanced novel devices for long-term monitoring of neural activity and neuromodulation.
Angulo-Garcia D, Berke JD, Torcini A (2016). “Cell Assembly Dynamics of Sparsely-Connected Inhibitory Networks: A Simple Model for the Collective Activity of Striatal Projection Neurons.” PLoS Comput Biol. 12(2):e1004778.
Mallet N, Schmidt R, Leventhal D, Chen F, Amer N, Boraud T, Berke JD (2016). “Arkypallidal Cells Send a Stop Signal to Striatum.” Neuron. 89(2):308-16.
Gritton HJ, Howe WM, Mallory CS, Hetrick VL, Berke JD, Sarter M (2016). “Cortical cholinergic signaling controls the detection of cues.” Proc Natl Acad Sci U S A. 113(8):E1089-97.
Hamid AA, Pettibone JR, Mabrouk OS, Hetrick VL, Schmidt R, Vander Weele CM, Kennedy RT, Aragona BJ, Berke JD (2016). “Mesolimbic dopamine signals the value of work.” Nat Neurosci. 19(1):117-26.
Wu F, Tien LW, Chen F, Berke J, Kaplan DL, Yoon E (2015). “Silk-backed structural optimization of high-density flexible intracortical neural probes.” IEEE Journal on Microelectromechanical Systems. 24:62-69.
Gittis AH, Berke JD, Bevan MD, Chan CS, Mallet N, Morrow MM, Schmidt R (2014). “New roles for the external globus pallidus in basal ganglia circuits and behavior.” J Neurosci. 34(46):15178-83.
Leventhal DK, Stoetzner C, Abraham R, Pettibone J, DeMarco K, Berke JD (2014). “Dissociable effects of dopamine on learning and performance within sensorimotor striatum.” Basal Ganglia. 4(2):43-54.
Freeze BS, Kravitz AV, Hammack N, Berke JD, Kreitzer AC (2013). “Control of basal ganglia output by direct and indirect pathway projection neurons.” J Neurosci. 33(47):18531-9.
Schmidt R, Leventhal DK, Mallet N, Chen F, Berke JD (2013). “Canceling actions involves a race between basal ganglia pathways.” Nat Neurosci. 16(8):1118-24.
Leventhal DK, Gage GJ, Schmidt R, Pettibone JR, Case AC, Berke JD (2012). “Basal ganglia beta oscillations accompany cue utilization.” Neuron. 73(3):523-36.