Reasearch Areas
  • Speech neurophysiology
  • Electrocorticography
  • Neuroprostheses

Edward Chang

Associate Professor, University of California, San Francisco

Edward Chang MD is Co-Director of CNEP and Associate Professor of Neurological Surgery and Physiology at UCSF. Dr. Chang’s clinical expertise is surgical therapies for intractable epilepsy, trigeminal neuralgia, pain, and adult brain tumors. He specializes in advanced neurophysiologic brain mapping methods, including awake speech and motor mapping, to safely perform neurosurgical procedures in eloquent areas of the brain. Dr Chang’s research focuses on the neural mechanisms underlying our ability to speak and hear speech. His lab is translating this knowledge into a neuroprosthetic device that will allow paralyzed patients to speak and communicate.


Bouchard KE, Mesgarani N, Johnson K, Chang EF. Functional organization of human sensorimotor cortex for speech articulation. Nature 2013 Mar21;495(7441):327-32.

Chang EF*, Niziolek C*, Nagarajan SS, Knight RT, Houde JS. Human cortical sensorimotor network underlying feedback control of vocal pitch. Proceedings of the National Academy of Sciences 2013 Feb 12;110(7):2653-8.

Cheung C, Chang EF. Real-time, single-trial mapping of cortical event-related activation. Journal of Neural Engineering 2012 Aug;9(4):046018.

Mesgarani N & Chang EF. Selective cortical representation of attended speech in multi-talker speech perception. Nature 2012 May 10; 485(7397):233-6.

Pasley B, David SV, Mesgarani N, Flinker A, Shamma SA, Crone NE, Knight RT, Chang EF. Reconstructing speech from human auditory cortex. PLoS Biology 2012 Jan; 10(1). PMCID: PMC3269422.

Chang, EF*, Rieger, J*, Johnson, KD, Berger, MS, Barbaro, NM, Knight RT. Categorical speech representation in the human superior temporal gyrus. Nature Neuroscience 2010 Nov; 13(11):1428-32. PMCID: PMC2967728.